Biomedical Sciences

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Even though immunotherapy has shown great potential in improving outcomes for patients with cancer, particularly through a combination of agents targeting immune inhibitory pathways, how to optimally combine the many new immunotherapy agents being de...

  • Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signaling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Drugs especia...

  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...

  • Magic™ pH-Sensitive Dye for Internalization Detection

    Magic™ pH-Sensitive Dye for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    For compounds against intracellular targets, internalization ability is one crucial characteristic, as they will rely on this process to confer their intended effects. Particularly, antibodies with internalization potencies can also act as excellent ...

  • UGT Investigation

    UGT Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-drug interaction (DDI) is a major concern when multiple drugs are co-administrated and interfere the metabolism of one another. In effort to minimize DDI liability, a comprehensive understanding of drug metabolism pathway and interference potenc...

  • CYP Investigation

    CYP Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    A drug-drug interaction occurs when two or more drugs are administrated simultaneously. Certain components of one drug may exert inducing or inhibiting effects on the metabolism of another drug by interfering the relevant enzymes, thus causing drug i...

  • Drug Distribution

    Drug Distribution

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Proteins in blood can greatly influence the drug distribution in tissues. They influence a drug distributes from blood into tissues as well as from tissues to action sites. Only drugs that are unbound to components in the blood are free to diffuse ac...

  • Physicochemical Characterization

    Physicochemical Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Physicochemical properties of drugs include the aspects of ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds are the fundamental for drug ...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Target deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...

  • Time-Kill Analysis for Fungi

    Time-Kill Analysis for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Time-kill curve assay is a broth-based method, and the rate of killing a fixed inoculum fungus is determined by comparing control group (no drug) and experiment group (antimicrobial agent-containing). The kill curves are constructed by plotting the C...

  • Dose-Response Relationship

    Dose-Response Relationship

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Studying dose response, and developing dose-response models, is vitally important for determining dosages for drugs. The dose-response relationship describes the change in effect on an organism caused by differing levels of drug doses after a certain...

  • Drug Repurposing

    Drug Repurposing

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    In silico drug repositioning refers to utilize online public databases and bioinformatics tools to identify interaction networks between drugs and targets. As years of accumulation of structure information of proteins and therapeutic compounds, Creat...