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Characterization and functional analysis of a novel cancer-associated gene
PhD Studentships Liverpool May 15, 2016 Check with publisherGenes involved in common biological processes and diseases tend to be co-expressed. Therefore, genes co-expressed with known disease-associated genes will help identify new candidates for further studies. Our lab has recently developed a co-expressio...
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DrugAge database of compounds that increase lifespan
Biomedical Sciences Liverpool August 24, 2015 Check with publisherWe're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...
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Expertise in genomics and transcriptomics
Data Analysis - Analytics August 24, 2015 Check with publisherI lead the Integrative Genomics of Ageing Group (http://pcwww.liv.ac.uk/~aging/), and I have extensive experience in data analysis and integration of multidimensional data. Although my lab’s research integrates different strategies, its focal point i...
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Indomethacin-Induced Rodent Inflammation in Small Intestine
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherCrohn's disease (CD) is a chronic condition observed in human and animal species affecting the gastrointestinal tract. It is one of the forms of Inflammatory Bowel Disease (IBD) complex, while the other being Ulcerative Colitis (UC). Animal models fo...
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Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherImmune checkpoint inhibitors have been regarded as a powerful new class of anticancer therapy. They have changed the clinical treatment method for a series of tumor types, including melanoma, non-small cell lung cancer, breast cancer, etc. Nowadays, ...
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Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherImmune checkpoint inhibitors, which target coinhibitory T cell molecules to promote anticancer immune responses, are now regarded as a novel cancer therapy of enormous potential. Nowadays, defining new targets and combination of immune checkpoint inh...
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Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherCo-inhibitory or immune checkpoint receptors have a key function in the maintenance of immune homeostasis: their expression on effector T cells allows the proper contraction of effector T cell responses and their expression on regulatory T (Treg) cel...
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Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherThe therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...
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Ovariectomy (OVX)-Induced Osteoporosis in Rats
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherOsteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures. The incidence of osteoporosis increases with age and occurs most frequently ...
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Transposon-Mediated Genome Manipulation
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherTransposons-based genetic strategies have been established in vertebrate species over the last decade. The major advantage of these strategies is that they facilitate analysis of gene function in an easy, controlled, and scalable manner, thereby avoi...
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Reference Standard Preparation and Characterization
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherA reference standard material is defined as highly purified compound that is well characterized by FDA (US Food and Drug Administration), and highly characterized specimens of drug substances, excipients, reportable impurities, degradation products, ...
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Magic™ Humanized CD40 Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherThe TNFR (Tumor Necrosis Factor Receptor) superfamily members are considered as appealing candidates for the development of targeted immunotherapies. Recently, a great attention has been focused upon a member of TNFR superfamily, CD40 (also known as ...
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Magic™ Humanized TIM-3 Immune Checkpoint Knock-In Mice
Molecular Biology Shirley (New York) October 30, 2019 Check with publisherT-cell inhibitory receptor TIM-3 (T-cell immunoglobulin and mucin domain 3) is expressed on Th1, Th17, CD8+ T cells and it is a T cell inhibitory receptor. TIM family is a kind of membrane protein, which contains three parts: a variable immunoglobuli...
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Magic™ Humanized CTLA-4 Immune Checkpoint Knock-In Mice
Molecular Biology Shirley (New York) October 30, 2019 Check with publisherAs a leading provider in the field of antibody discovery, development and manufacture, Creative Biolabs has successfully launched, commercialized and optimized an exclusive Magic™ therapeutic antibody discovery platform. Of note, as increasing attent...
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Anti-Denv-1 Polyprotein Antibody
Biological Sciences Shirley (New York) October 29, 2019 Check with publisherThis product is a mouse antibody that specifically recognizes Polyprotein from Denv-1. The antibody 15F3-1 is an epitope-specific antibody that can be used in WB, ELISA, Inhib and other immunological assays. Dengue virus (DENV) in one of four serotyp...
