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  • Characterization and functional analysis of a novel cancer-associated gene

    Characterization and functional analysis of a novel cancer-associated gene

    PhD Studentships Liverpool May 15, 2016 Check with publisher

    Genes involved in common biological processes and diseases tend to be co-expressed. Therefore, genes co-expressed with known disease-associated genes will help identify new candidates for further studies. Our lab has recently developed a co-expressio...

  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

  • Expertise in genomics and transcriptomics

    Expertise in genomics and transcriptomics

    Data Analysis - Analytics August 24, 2015 Check with publisher

    I lead the Integrative Genomics of Ageing Group (http://pcwww.liv.ac.uk/~aging/), and I have extensive experience in data analysis and integration of multidimensional data. Although my lab’s research integrates different strategies, its focal point i...

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  • Permeability and Absorption

    Permeability and Absorption

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The Caco-2 cell line is derived from a human colon carcinoma and has many characteristics that resemble intestinal epithelial cells. Caco-2 permeability assay is a good way to investigate human intestinal permeability and drug efflux. Caco-2 permeabi...

  • Pharmaceutical Stability Testing

    Pharmaceutical Stability Testing

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The purpose of these two programs is intended to identify the likely degradation products which further helps in determining the intrinsic stability of the molecule, establishing degradation pathways, and validating the stability indicating procedure...

  • Lipophilicity

    Lipophilicity

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Shake-flask procedure is a simple extraction in octanol/water system under shaking. After equilibrium between all interacting components is attained, samples are collected from both phases, and concentrations in each phase are quantified with LC-MS/M...

  • Aqueous Solubility

    Aqueous Solubility

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Solubility refers to the phenomenon that solute dissolving in a solvent to give a homogeneous system. A drug needs to dissolve in the systemic circulation and achieves desired concentration to produce a desirable pharmacological response. Low aqueous...

  • Physicochemical Characterization

    Physicochemical Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Physicochemical properties of drugs include the aspects of ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds are the fundamental for drug ...

  • Interference with Fungal Cell Membrane

    Interference with Fungal Cell Membrane

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The emerging technology of whole-genome sequencing enables exploration of therapeutic targets against pathogenic fungi to a previously unprecedented extent. However, no matter in the past or present, fungal cell membrane has always been a predominant...

  • Interference with Fungal Protein Synthesis

    Interference with Fungal Protein Synthesis

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Fungal cell envelope (plasma membrane and cell wall) has long been taken as the primary target for developing most antifungal therapies, for their well-characterized structure, easy access, and adequate pathogenicity. However, the increasing impact o...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Target deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...

  • Post Antifungal Effect (PAFE)

    Post Antifungal Effect (PAFE)

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The post antifungal effect (PAFE) refers to growth suppression of surviving fungi following the removal of antifungals in the absence of host defense mechanisms. It is a phenomenon which is observed both in vitro and in vivo. Antifungals are capable ...

  • Time-Kill Analysis for Fungi

    Time-Kill Analysis for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Time-kill curve assay is a broth-based method, and the rate of killing a fixed inoculum fungus is determined by comparing control group (no drug) and experiment group (antimicrobial agent-containing). The kill curves are constructed by plotting the C...

  • Dose-Response Relationship

    Dose-Response Relationship

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Studying dose response, and developing dose-response models, is vitally important for determining dosages for drugs. The dose-response relationship describes the change in effect on an organism caused by differing levels of drug doses after a certain...

  • Antimicrobial Pharmacodynamics

    Antimicrobial Pharmacodynamics

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Creative Biolabs provides both broth-based and agar-based assays for evaluating MIC. For broth-based assays, broth macrodilution and broth microdilution are provided. For agar-based assays, disk diffusion, Etest, and colorimetric assays are provided....