Premium listings
-
Characterization and functional analysis of a novel cancer-associated gene
PhD Studentships Liverpool May 15, 2016 Check with publisherGenes involved in common biological processes and diseases tend to be co-expressed. Therefore, genes co-expressed with known disease-associated genes will help identify new candidates for further studies. Our lab has recently developed a co-expressio...
-
DrugAge database of compounds that increase lifespan
Biomedical Sciences Liverpool August 24, 2015 Check with publisherWe're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...
-
Expertise in genomics and transcriptomics
Data Analysis - Analytics August 24, 2015 Check with publisherI lead the Integrative Genomics of Ageing Group (http://pcwww.liv.ac.uk/~aging/), and I have extensive experience in data analysis and integration of multidimensional data. Although my lab’s research integrates different strategies, its focal point i...
Listings
-
Permeability and Absorption
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherThe Caco-2 cell line is derived from a human colon carcinoma and has many characteristics that resemble intestinal epithelial cells. Caco-2 permeability assay is a good way to investigate human intestinal permeability and drug efflux. Caco-2 permeabi...
-
Pharmaceutical Stability Testing
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherThe purpose of these two programs is intended to identify the likely degradation products which further helps in determining the intrinsic stability of the molecule, establishing degradation pathways, and validating the stability indicating procedure...
-
Lipophilicity
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherShake-flask procedure is a simple extraction in octanol/water system under shaking. After equilibrium between all interacting components is attained, samples are collected from both phases, and concentrations in each phase are quantified with LC-MS/M...
-
Aqueous Solubility
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherSolubility refers to the phenomenon that solute dissolving in a solvent to give a homogeneous system. A drug needs to dissolve in the systemic circulation and achieves desired concentration to produce a desirable pharmacological response. Low aqueous...
-
Physicochemical Characterization
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherPhysicochemical properties of drugs include the aspects of ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds are the fundamental for drug ...
-
Interference with Fungal Cell Membrane
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherThe emerging technology of whole-genome sequencing enables exploration of therapeutic targets against pathogenic fungi to a previously unprecedented extent. However, no matter in the past or present, fungal cell membrane has always been a predominant...
-
Interference with Fungal Protein Synthesis
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherFungal cell envelope (plasma membrane and cell wall) has long been taken as the primary target for developing most antifungal therapies, for their well-characterized structure, easy access, and adequate pathogenicity. However, the increasing impact o...
-
Mode of Action (MOA) Determination for Fungi
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherTarget deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...
-
Post Antifungal Effect (PAFE)
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherThe post antifungal effect (PAFE) refers to growth suppression of surviving fungi following the removal of antifungals in the absence of host defense mechanisms. It is a phenomenon which is observed both in vitro and in vivo. Antifungals are capable ...
-
Time-Kill Analysis for Fungi
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherTime-kill curve assay is a broth-based method, and the rate of killing a fixed inoculum fungus is determined by comparing control group (no drug) and experiment group (antimicrobial agent-containing). The kill curves are constructed by plotting the C...
-
Dose-Response Relationship
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherStudying dose response, and developing dose-response models, is vitally important for determining dosages for drugs. The dose-response relationship describes the change in effect on an organism caused by differing levels of drug doses after a certain...
-
Antimicrobial Pharmacodynamics
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherCreative Biolabs provides both broth-based and agar-based assays for evaluating MIC. For broth-based assays, broth macrodilution and broth microdilution are provided. For agar-based assays, disk diffusion, Etest, and colorimetric assays are provided....
