Premium listings
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Characterization and functional analysis of a novel cancer-associated gene
PhD Studentships Liverpool May 15, 2016 Check with publisherGenes involved in common biological processes and diseases tend to be co-expressed. Therefore, genes co-expressed with known disease-associated genes will help identify new candidates for further studies. Our lab has recently developed a co-expressio...
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Expertise in genomics and transcriptomics
Data Analysis - Analytics August 24, 2015 Check with publisherI lead the Integrative Genomics of Ageing Group (http://pcwww.liv.ac.uk/~aging/), and I have extensive experience in data analysis and integration of multidimensional data. Although my lab’s research integrates different strategies, its focal point i...
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DrugAge database of compounds that increase lifespan
Biomedical Sciences Liverpool August 24, 2015 Check with publisherWe're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...
Listings
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Pracinostat (SB939)
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide; Pracinostat Description: Potent and oral inhibitor of histone deacetylase (HDAC), selective for class I, II and IV HDACs. SB 939 demonstrates ...
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Salermide
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherAbbr: Salermide(SIRT1, SIRT2) Synonyms: N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide Description: Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitor...
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Vorinostat (SAHA)
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: Vorinostat; Suberanilohydroxamic Acid; MK-0683 Description: Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Prevents diabetes in a mouse model by immunoregulation and β-cell pretection. Cell permeable. Appearanc...
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Ryuvidine
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Description: Ryuvidine is a potent inhibitor of SET domain-containing protein 8 (SETD8) (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro. It displays weak inhibiton ...
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Ruxolitinib, Free base
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: INCB018424; INC18424; NCB018424; NCB18424 Description: Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with IC₅₀'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibros...
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RSC133
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide Description: RSC-133 is an epigenetic modulator that effectively improves reprogramming of human somatic cells to pluripotent stem cells. Apparently, RSC-133 facilitates the re...
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Ro 31-8220 methanesulfonate
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone; Mallotoxin Description: Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However,...
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Ro 31-8220 methanesulfonate
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX Description: Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isof...
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RG 108
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: RG-108, N-Phthalyl-L-tryptophan; or (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid Product Overview: A DNA methyltransferase (DNMT) inhibitor Description: A DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylatio...
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Remodelin
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherynonyms: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile Description: Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells v...
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Quercetin, Dihydrate
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 3,5,7,3',4'-Pentahydroxyflavone Description: A plant-derived flavanoid. Cell-permeable. Inhibits PIM1 kinase (IC₅₀ = 1.1 µM), PI 3-Kinase (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM). Also acts as an anti-tumor agent; induces apoptosi...
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Quercetin, Dihydrate
Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisherSynonyms: 3,5,7,3',4'-Pentahydroxyflavone Description: A plant-derived flavanoid. Cell-permeable. Inhibits PIM1 kinase (IC₅₀ = 1.1 µM), PI 3-Kinase (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM). Also acts as an anti-tumor agent; induces apoptosi...
